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2 edition of Studies on metabolism and inhibition of melanoma mouse cell line found in the catalog.

Studies on metabolism and inhibition of melanoma mouse cell line

Sylvie Wagner

Studies on metabolism and inhibition of melanoma mouse cell line

by Sylvie Wagner

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Published by Laurentian University in Sudbury, Ont .
Written in English


Edition Notes

Statementsubmitted by Sylvie Wagner.
The Physical Object
Pagination1 v. :
ID Numbers
Open LibraryOL22161916M

Brain metastasis of a VE B-raf-mutated melanoma, from Wikimedia. The VE mutation is common in melanomas and hairy cell leukemia and is also found in some other types of cancer. Research in mice suggests that acetoacetate, whose presence in the body can be elevated by high-fat, low-carb diets, spurs the growth of cancers with the VE. The metastatic capacity of intravenously injected human FEMX-I melanoma cells in athymic nude mice and rats was compared. Young rats given 1 x 10 6 ascites tumor cells all died of lung tumors with a life span of 50 ± 10 days (mean ± SD). In contrast, in accordance with previous findings, only extrapulmonary metastases developed in by: 9.

ATCC stands ready to support our customers’ needs during the coronavirus pandemic. Our first job is to listen to and observe what our customers need, and meet those needs with quality products and services. Several studies in mice that develop malignant melanoma show a role of UVB in melanoma genesis, in contrast to this, the role of UVA is less clear. It has been demonstrated that UVB can activate an important differentiation and proliferation signaling pathway, the MAPK pathway, leading to AP1 translocation to nucleus [ 2 ].Cited by: 2.

  Thus, the KIM-2 cell line will be of value in future studies on early transcription events in the apoptotic process. The low copy number line of BLG/SV40tsT mice can be crossed with other mice that harbouring either transgenes or gene deletions, thereby allowing the isolation of mammary cell lines from interesting mouse by:   UT Southwestern Medical Center. (, November 7). Spread of human melanoma cells in mice correlates with clinical outcomes in patients. ScienceDaily. Retrieved March 9, from www.


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Studies on metabolism and inhibition of melanoma mouse cell line by Sylvie Wagner Download PDF EPUB FB2

Tested in combination with BRAF inhibitor in BRAF mutant melanoma cell lines: n.d. Mitochondrial HSP Gamitrinib (Pre-clinical data) Inhibition of mitochondrial biogenesis and bioenergetics: Tested alone or in combination with BRAF inhibitor in melanoma cell lines in vitro and in mouse xenografts-Patient-derived xenograft modelsCited by: After 3–4 weeks of inoculation of B16 cells at C57BL/6J mice, histological studies revealed the presence of malignant melanoma and metastasis in liver, lungs and spleen, showing that the B16 mouse melanoma model is an easy to reproduce in vivo model of carcinogenesis [24,25], with liver presenting a moderate stasis and a spot-type tumor Cited by:   Several cell lines have been used for syngeneic transplantations, including Harding-Passey cells isolated from the ICR mouse ear and the Cloudman S91cell line obtained from the DBA mouse The most widely used cell type, though, has been the B16 cell line that spontaneously forms tumor after chemical induction of melanoma in C57BL/6J mice and Cited by: Melanoma is the less common but the most malignant skin cancer.

Since the survival rate of melanoma metastasis is about 10–15%, many different studies have been carried out in order to find a. David Weedon AO MD FRCPA FCAP(HON), in Weedon's Skin Pathology (Third Edition), Small cell melanoma. Small cell melanoma refers to the presence of cells resembling those seen in a Merkel cell carcinoma (see p.

).It has also been used for a variant of nevoid melanoma (see below), but some cases of nevoid melanoma composed of small cells are included in the category of small cell.

Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor : Yan Li, Lisa Elmén, Igor Segota, Yibo Xian, Roberto Tinoco, Yongmei Feng, Yu Fujita, Rafael R.

Segur. Cotreatment of BRAF-mutated melanoma cell lines with phenformin and PLX resulted in synergistic inhibition of cell viability, compared with the effects of the single agent alone. By developing cell lines that grow readily in culture, investigators have created a fast-track research tool that remains applicable to many scientists who use mouse melanoma as a model system.

Employing in vitro methodology and new staining techniques, changes in karyotype of a heteroploid tumor cell line derived from a pulmonary metastasis of a malignant melanoma were studied over 10 months of continuous cultivation. The modal karyotype of tumor cells in a 3-week-old culture was composed of 41 intact and 11 marker chromosomes.

These markers contained three paired (disomic) Cited by:   Malignant melanoma is characterized by the development of chronic inflammation in the tumor microenvironment, which leads to a strong immunosuppression associated with a rapid tumor progression.

Adenosine is considered as one of the main immunosuppressive factors in the tumor environment. It is produced via enzymatic hydrolysis of extracellular ATP by ectonucleotidases CD39 Cited by: Roh-Johnson et al. show that macrophages transfer cytoplasmic molecules to tumor cells via cell contact in zebrafish and mouse.

Cytoplasmic transfer correlates with increased tumor cell dissemination in vivo and altered tumor cell migration in vitro. These results uncover a mode of contact-dependent cell-to-cell communication in the tumor by:   In mouse xenografts of the RCC cell line Caki-1, tumor growth was inhibited by treatment with CB alone, but the combination with either cabozantinib or everolimus inhibited tumor growth more effectively than either agent alone (Calithera Biosciences, Inc., unpublished data, see ref.).Cited by: 6.

Nakai S, et al. A simple, sensitive bioassay for the detection of interleukin-1 using human melanoma A cell line. Biochem. Biophys. Res. Commun.PubMed: Giard DJ, et al. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.

Natl. Cancer Inst. Recent studies have suggested that adenosine generated by ecto-5′-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulating angiogenesis via A2A and A2B receptors.

However, adenosine has also been reported to inhibit tumor growth acting via A1 and A3 receptors. Therefore the aim of this study was to Cited by: @article{osti_, title = {Inhibition of cell proliferation, migration and invasion of BF10 melanoma cells by α-mangostin}, author = {Beninati, Simone and Oliverio, Serafina and Cordella, Martina and Rossi, Stefania and Senatore, Cinzia and Liguori, Immacolata and Lentini, Alessandro and Piredda, Lucia and Tabolacci, Claudio and Department of Hematology, Oncology and Molecular.

Melanotransferrin (MTf) or melanoma tumor antigen p97 is a transferrin (Tf) homolog that is found predominantly bound to the cell membrane via a Cited by: @article{osti_, title = {Specificity of growth inhibition of melanoma by 4-hydroxyanisole}, author = {Kulkarni, G A and Nathanson, L}, abstractNote = {An experimental study using human melanoma (NEL-MI), rat hepatoma (Fu), and human kidney () cell lines was undertaken in order to evaluate the antitumor activity of 4-hydroxyanisole (4-OHA) in vitro.

The effect of sickle cell disease (SCD) on tumor growth is unknown. Sickled red blood cells may form aggregates within the microvasculature of hypoxic tumors and reduce blood flow leading to impairment of tumor growth.

However, there is a paucity of data related to tumor growth in SCD. To investigate the effect of SCD on tumor growth in a melanoma model, we generated SCD and control Cited by: 2. Deregulated melanogenesis is involved in melanomagenesis and melanoma progression and resistance to therapy.

Vitamin D analogs have anti-melanoma activity. While the hypercalcaemic effect of the active form of Vitamin D (1,25(OH)2D3) limits its therapeutic use, novel Vitamin D analogs with a modified side chain demonstrate low calcaemic activity. We therefore examined the effect of Cited by: INTRODUCTION.

Melanoma is among the most common cancers in the United States, causing approximatelynew cases and deaths annually [].Worldwide, melanoma accounts for approximatelynew cases deaths annually []. (See "Risk factors for the development of melanoma", section on 'Epidemiology'.).

Although patients with localized disease can be treated. 4T1 tumour cell line, a recognized model for breast cancer studies originally isolated by Miller and colleag58 was exploited.

4T1 cell injection Cited by: 7. GC-MS. Cell pellets (1–5 × 10 6 cells) were resuspended in ml of cold (−20 °C) 50% methanol (in water) containing μ m 2-amino-butyrate or μ m l-norvaline (internal standard), left to freeze on dry ice for 30 min, then thawed on ice for 10 min before liquid phase was removed to a separate tube, and ml of chloroform with 4 μg/ml C fatty acid.Melanoma, which is the most malignant skin cancer type, has got one of the fastest increasing incidence rates of all cancer types in the world.

When belatedly diagnosed, melanoma is extremely invasive and metastatic. Although there are effective drugs used to treat melanoma, some cell lines have proven resistant to chemotherapy. In this context, several research groups on natural products have Author: Raimundo Gonçalves de Oliveira Júnior, Christiane Adrielly AlvesFerraz, Mariana Gama e Silva, Érica.